Is it Safe to Continue Medication When You Can't Keep Food Down?
At 26 years of age, I am currently prescribed Midodrine, which I take three times daily. Unfortunately, I have been unable to maintain a proper diet for the past 12 days, only managing a few small bites here and there. I am concerned whether I should continue taking Midodrine during this period of nutritional deprivation, as I worry it might lead to further complications. I have a gastrointestinal appointment scheduled in a few months to address a persistent GI issue I've been experiencing on and off for a year. At the moment, I seem to be experiencing another flare-up. Whenever I consume food, I end up vomiting, eating becomes painful, and I endure stomach discomfort. The only relief I find is from taking 8 mg of Zofran three times daily, despite that I still cannot eat much (I really do try!). Additionally, I've noticed I feel full much quicker than normal. Midodrine is essential for managing my Postural Orthostatic Tachycardia Syndrome (PoTS), and I'm unsure how I would cope without it. My medical history includes an unidentified gastrointestinal disorder, PoTS, and Long COVID. Currently, my medications include Zofran and Midodrine.
Answers (1)

7/6/2025, 7:50:34 PM
OpenHealth AI
It's understandable to be concerned about continuing your medication when you're struggling to keep food down. Midodrine helps manage your Postural Orthostatic Tachycardia Syndrome (PoTS), but taking medication while you're not eating can have implications. Here’s what to consider:
Explanation
- Midodrine can cause side effects such as increased blood pressure, and if you’re eating less, your body might respond differently to the medication. It’s essential to maintain a safe blood pressure level, especially since PoTS can cause symptoms when standing.
- Zofran (ondansetron) is commonly used to manage nausea and vomiting, and it may help you maintain some food intake despite the challenges.
- Nutritional concerns arise when food intake is significantly reduced over time, as it may affect your overall health and the efficacy of medications.
Next Steps
- Monitor your symptoms: Keep a journal of your food intake, how often you vomit, and any new symptoms. This will be helpful for your upcoming GI appointment.
- Continue taking Midodrine: It is crucial to manage your PoTS, but if you feel unwell after taking it without food, consider adjusting the timing. It may be best taken when you can eat or have at least a small amount in your stomach.
- Prioritize hydration: Since you're unable to eat well, focus on staying hydrated. Consider sipping on electrolyte solutions or broths.
- Use Zofran as needed: Continue taking your prescribed Zofran. If you find that even this isn't helping, note this for your doctor.
- Reach out for advice sooner if needed: If your vomiting worsens, you experience severe dizziness, dehydration, or significant weight loss, seek medical attention sooner rather than later.
Lastly, it's great that you have a GI appointment scheduled, as that will give you an opportunity to discuss these issues further. Your health concerns are important, and addressing them proactively is the best approach. Take care, and keep me posted on your progress.
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