Unexpected Red Rash Following Vaccination
I’m a 36-year-old woman, weighing 115 pounds and standing at 5’3”, who received the p23 vaccine yesterday. After the shot, the injection site has been quite sore. However, just as I was settling in for the night, I noticed an itchiness, followed by the emergence of a raised red rash. Remarkably, there are two distinct lines extending from the center of my upper arm, where the vaccine was administered. While that area features a considerable red swelling, the lines heading toward my armpit are particularly unusual; I’ve never experienced anything like this before. I tracked their growth with a pen, and within about half an hour, they lengthened significantly. Though the itching has subsided, the affected region feels warm to the touch and appears slightly swollen. Although it’s likely just a typical post-vaccination response, the rapid development of these lines connecting my arm to my armpit raises some concern. Better to be cautious, right? I would have liked to share a photo, but it seems I can’t upload one. Any thoughts would be appreciated.
Answers (1)

7/4/2025, 4:40:34 AM
OpenHealth AI
It’s understandable to feel concerned about changes in your skin following vaccination, especially with the rapid development of a rash and swelling. Let’s break down what's happening and what you can do next.
Main Points:
- Post-vaccination reactions, including itching and redness at the injection site, can be common.
- The rash and swelling you’re describing may be a localized reaction, although the unusual lines extending toward your armpit warrant observation.
Explanation:
After receiving a vaccine, it’s not uncommon for the body to react at the injection site with soreness, redness, and swelling. This can be your immune system responding to the vaccine, which is a normal process. However, sudden changes like the raised red rash and lines extending from the injection site can be concerning. These symptoms could be indicative of an allergic reaction or a specific skin response to the vaccine.
Next Steps:
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Monitor the Rash: Keep an eye on the rash for the next 24-48 hours. Note any changes in size, color, or sensitivity. Since you've already tracked its growth, continue to observe it closely.
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Cool Compress: Apply a cool, damp cloth to the affected area for 10-15 minutes to help reduce itching and swelling.
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Avoid Irritants: Make sure to avoid tight clothing over the area and refrain from scratching it, as this can worsen irritation.
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Over-the-Counter Remedies: Consider taking an antihistamine (like diphenhydramine) to help with any itching or discomfort, if you are not allergic to those medications.
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Seek Care if Necessary: If the rash worsens, if you develop symptoms like fever, difficulty breathing, or if you notice any spreading of the rash beyond the arm, it’s important to seek medical advice promptly.
Remember, while many reactions can be benign, it’s always best to err on the side of caution and observe any new or worsening symptoms. You’re doing great by keeping track of the changes and being proactive about your health! If you have any more questions or concerns, feel free to ask.
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