Unexpected Injection Confusion: Methylprednisolone Administered Instead of Depo-Provera
My sister, who is 36 years old, weighs 135 lbs and stands at 4'11", went to receive her medroxyprogesterone acetate shot today. Upon returning home with my mom, they discovered that an injection of methylprednisolone had been administered by mistake. My sister has special needs, and my mom, often relying on online information, didn’t ask any questions, leaving me with minimal details about the incident. I am particularly worried about whether she received 150 mg of the methylprednisolone, which is the same dosage as the medroxyprogesterone. She has no existing medical issues. I understand that injectable steroids usually don’t require a tapering process, but I’m wondering if there are any specific side effects to be aware of besides the common ones like fluid retention and potential weight gain. Are there any additional risks or symptoms I should monitor for?
Answers (1)

7/3/2025, 1:20:41 AM
OpenHealth AI
It's understandable to be concerned about your sister receiving the wrong injection. Methylprednisolone is a corticosteroid that can have side effects, but the risks depend on the dosage, duration of use, and individual health factors.
Key Points:
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Potential Side Effects of Methylprednisolone: Common side effects include fluid retention, weight gain, increased appetite, and mood changes. More serious effects can include elevated blood sugar levels, increased risk of infections, and changes in blood pressure.
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Dosage Consideration: If your sister did indeed receive the same dosage as the medroxyprogesterone acetate shot (150 mg), it's still important to note that this amount could be concerning if there are unexpected reactions, especially in someone without pre-existing health issues.
Explanation:
Methylprednisolone works by reducing inflammation and suppressing the immune system. While it can be beneficial for certain conditions, it can also lead to side effects, particularly when used in higher doses or for longer periods. It's important to watch for not just the common side effects you mentioned, but also more serious reactions.
Next Steps:
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Monitor for Side Effects: Keep an eye on her closely for the following symptoms:
- Increased Thirst and Hunger: Changes in appetite or thirst could indicate changes in blood sugar levels.
- Mood Changes: Track any unusual mood swings or mental confusion.
- Signs of Infection: Look for symptoms such as fever, aches, or other indicators of infection, which may arise due to immune suppression.
- Fluid Retention: Notice any swelling in her feet or legs and unexpected weight gain.
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Document Symptoms: If any side effects occur, make detailed notes. Track dates, severity, and any other relevant changes.
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Stay Informed: Encourage your mother to ask questions during such situations in the future. It's important to understand what medication is being administered.
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Emergency Signs: Be vigilant for severe side effects such as shortness of breath, severe depression, or signs of an allergic reaction (like rash or difficulty breathing), and be prepared to seek immediate medical assistance if these occur.
In general, while methylprednisolone doesn’t usually require a tapering process when given as a single injection, keeping a close observation is key. If you're ever uncertain or if your sister shows any concerning symptoms, reach out for professional medical advice as soon as possible. It's better to ask and be safe.
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