Is Hallucination Linked to Cymbalta Use?
I’m reaching out on behalf of my father, who is a 70-year-old man with diagnoses of atrial fibrillation and hypertension. He is currently taking medication for his blood pressure and Xarelto. He also uses marijuana occasionally and consumes alcohol a few times a week. Recently, my father has been showing signs of cognitive decline and memory problems that appear to be worsening. Although he has always had a tendency to become frustrated easily and has struggled with emotional regulation, his levels of anger and agitation have noticeably increased in the past six months. Moreover, he has been experiencing confusion, as well as hallucinations and delusions, which seem to have started around the same timeframe. Three months ago, he was prescribed Cymbalta in response to feelings of depression, and since then, his symptoms, including episodes of hallucinations and cognitive deterioration, seem to have escalated. His cardiologist suspects that these issues might be a side effect of Cymbalta. While I recognize that such reactions can occur, I am not entirely convinced that this is the sole cause, and I am concerned it could be indicative of a more serious condition like dementia. I would appreciate any opinions from professionals in this area. Should I be advocating for him to consult with a neurologist? Thank you for any advice or insights you can provide.
Answers (1)

7/1/2025, 6:40:43 PM
OpenHealth AI
It's concerning to hear about your father's cognitive decline, hallucinations, and increased agitation. These symptoms can certainly arise from various factors, including medication side effects, underlying health issues, or a combination of both.
Explanation:
Cymbalta (duloxetine) is an antidepressant that can sometimes cause side effects, including confusion and hallucinations, especially in older adults. Given your father's medical history, including atrial fibrillation and hypertension, and his concurrent use of alcohol and marijuana, it's important to consider all possible influences on his cognitive state. Hallucinations and significant changes in behavior can also be symptoms of neurological conditions like dementia or delirium.
Next Steps:
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Monitor Symptoms: Keep a detailed record of your father's symptoms, noting when they occur, their duration, and any possible triggers. This can provide useful information for healthcare providers.
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Medication Review: Speak with his primary care physician or the prescribing doctor about the potential side effects of Cymbalta in relation to his symptoms. There may be alternative medications that are less likely to contribute to cognitive issues.
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Evaluate Substance Use: Discuss with a healthcare professional the effects of alcohol and marijuana use, particularly in the context of dementia, as these substances could exacerbate cognitive decline.
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Neurological Consultation: Advocate for a comprehensive evaluation by a neurologist. Given the symptoms of hallucinations, memory problems, and changes in emotional regulation, a specialist can assess for conditions like dementia or other neurological disorders.
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Family Support: Keep communicating with your father and provide emotional support. Engage him in light conversations and activities to help maintain his cognitive function.
Addressing these concerns proactively is vital for your father's well-being. Should his symptoms worsen, or if new alarming signs arise, seek immediate medical attention.
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