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Understanding Recurrent False Positive Syphilis Test Results

6/30/2025, 5:10:23 AMMale25-34

I am a 28-year-old female, standing at 5 feet tall and weighing 170 pounds. I am of North African descent and have been facing a perplexing situation for the past five months regarding my health. I only take dietary supplements, which include Vitamin D, L-lysine, and occasionally Vitamin C, and I have no significant medical history to report. This situation began back in February when I underwent a routine sexually transmitted infection (STI) screening. The initial results showed a reactive test for syphilis antibodies (T. pallidum), which prompted additional testing. The subsequent RPR (Rapid Plasma Reagin) test, however, returned non-reactive, alongside confirmatory examinations. My physician speculated that a viral infection could have caused the false positive result and suggested I repeat the tests in 2 to 4 weeks. To my dismay, the same pattern emerged: another reactive result followed again by a non-reactive RPR. This cycle repeated itself several months later without any proactive follow-up from my doctor, who seemed to dismiss my inquiries on the condition. This leads me to question whether there might be a hidden cause or illness responsible for these inaccurate test results. I wonder what type of specialist I should consult for further evaluation and insight into this issue. For context, here are the dates of my test results: - February 25, 2025 - April 9, 2025 - May 19, 2025 It's important to note two things: first, I do not believe I have syphilis as I have had no known exposures and my tests prior to February were consistently negative. Second, I have not received any vaccinations recently that might have influenced the outcomes.

Multiple SclerosisLupusInternal Medicine

Answers (1)

Cony

6/30/2025, 5:10:43 AM

OpenHealth AI

It's understandable to feel perplexed by recurring false positive syphilis test results, especially when they have not aligned with your clinical history or exposure risk. Here’s an overview to address your concerns:

Summary of Key Points:

  • Recurring reactive syphilis test results followed by non-reactive RPR can suggest a false positive caused by various factors, including other infections or medical conditions.
  • Consultation with a specialist is recommended for further evaluation.

Explanation:

The initial reactive syphilis test indicates the presence of antibodies against the syphilis bacterium (T. pallidum). However, the RPR test is non-reactive, suggesting no active syphilis infection. The repeated pattern you've experienced could be attributed to several factors:

  • False Positives: Are possible due to specific viral infections, autoimmune conditions, or other factors such as elevated antibodies from previous infections or inflammatory conditions.
  • Testing Errors: It’s essential to ensure that quality control measures have been adhered to during testing and that proper processes are in place.

Next Steps:

  1. Documentation: Keep a thorough record of your test results, including dates and details. This can help during consultations with specialists.

  2. Consult a Specialist: It may be beneficial to see an infectious disease specialist or an internist, who can explore other potential causes for false positives and assess your medical history and any related symptoms more thoroughly.

  3. Consider Other Tests: Ask the specialist about additional tests that may help clarify your situation, such as:

    • Treponemal tests (e.g., FTA-ABS) which can give more specific results.
    • Tests for connective tissue diseases or autoimmune conditions if relevant.
  4. Monitoring: While you wait for your appointment, monitor any new symptoms, such as rashes, fevers, or joint pains, and report these to the specialist.

It's important to stay proactive about your health—feeling uncertain can be unsettling, but there are pathways to getting clear answers. Remember, you deserve thorough care and consideration regarding your health concerns. Let me know if you need more support or details.

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