Concerns Regarding Testosterone Therapy and Breast Tissue Development
I’m a 47-year-old male, standing at 5'5'' and weighing 185 lbs. Approximately a year ago, I began receiving testosterone injections, and I’m pleased to report that my hormone levels have finally reached an optimal range. The positive effects of this therapy have been remarkable; I’ve returned to the gym and managed to shed around 24 lbs. However, I've encountered a troubling issue that has become more prominent as I continue to lose weight: the emergence of breast tissue that doesn't seem to diminish with my weight loss. I brought this concern to my physician's attention, and she recommended that I take Anastrozole at a dosage of 1mg, once a week. Upon researching, I've found that many individuals typically take a dose of 1mg every other day for effectiveness. I’m apprehensive that if we proceed with this regimen for the next three to six months, I may not see any improvement or, worse, the situation could escalate. I’m seeking advice on whether there might be an alternative medication that could be more effective, or if Anastrozole is indeed suitable for my condition. Furthermore, will taking it just once a week yield significant benefits or improvements?
Answers (1)

6/28/2025, 5:01:04 PM
OpenHealth AI
It's great to hear that you've had positive results with your testosterone therapy and weight loss. However, I understand your concern regarding the emergence of breast tissue, which can be distressing. Here’s a breakdown of your situation, followed by actionable steps.
Main Points:
- Gynecomastia, or the development of breast tissue, is a known potential side effect of testosterone therapy.
- Anastrozole may help by lowering estrogen levels, but its effectiveness can vary based on dosage and individual response.
- Exploring further options and monitoring your situation carefully is essential.
Explanation:
Gynecomastia can occur for various reasons, including hormonal imbalances that may arise from testosterone therapy. Anastrozole is an aromatase inhibitor that reduces estrogen production, which may help manage breast tissue development. However, there’s a lack of consensus on the optimal dosage for mitigating these side effects; while some may see benefits from taking it every other day, others might do well with less frequent dosing.
Next Steps:
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Monitor Symptoms: Keep track of any changes in breast tissue size, tenderness, or related symptoms. Note these changes weekly and share them with your doctor.
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Feedback to Your Physician: After a few weeks of Anastrozole, discuss the effectiveness of the 1mg once-a-week dosage with your physician. If you feel no improvement, bringing up the possibility of increasing the frequency could be worthwhile.
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Consider Second Opinion: If you have ongoing concerns, it could be beneficial to consult an endocrinologist who specializes in hormone-related disorders. They might suggest alternatives such as adjusting your medication regimen or considering options like selective estrogen receptor modulators (SERMs).
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Lifestyle Adjustments: Continue your healthy lifestyle changes, including regular exercise and a balanced diet. This can support overall hormonal balance and may help with gynecomastia.
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Emotional Support: If this issue is affecting your mental health or self-esteem, consider reaching out to a counselor or support group specializing in body image or men's health.
Remember, it's essential to address your concerns with professionals who can provide tailored advice based on your specific health condition. Please feel free to ask more questions as you continue your treatment journey.
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