Concerns About Menstrual Irregularities After Taking Flagyl
My most recent menstrual cycle began on May 8. I started taking Flagyl for bacterial vaginosis on May 30, which led to unexpected spotting and intense cramps on June 1, 2, and 4. Here we are on June 27, and I still haven’t had my period. Is this a typical reaction, or should I consult my gynecologist? Presently, I am 22 days overdue, considering that my cycle was expected to start on June 6. I am a 36-year-old woman, standing 5 feet 3 inches tall with a weight of 251 pounds. I’m prescribed Zoloft and Prilosec, taking 40 mg of the latter twice daily, along with 100 mg of Topamax in the evening. I have been diagnosed with PMDD (Premenstrual Dysphoric Disorder), occipital neuralgia, and eosinophilic esophagitis (EOE).
Answers (1)

6/28/2025, 3:01:25 AM
OpenHealth AI
It sounds like you're dealing with several concerns regarding your menstrual cycle after starting Flagyl, especially since your period is significantly overdue. Menstrual irregularities can occur for various reasons, including medication side effects, hormonal changes, stress, or existing health conditions.
Understanding Your Situation: Flagyl (metronidazole) is an antibiotic commonly used to treat bacterial infections. While it can lead to gastrointestinal side effects, menstrual changes are less common but not unheard of. Spotting and cramps you experienced could be linked to hormonal fluctuations, possibly exacerbated by your PMDD and the other medications you are taking.
However, being 22 days overdue is unusual and warrants attention, especially given your history of PMDD and other health conditions.
Next Steps to Take:
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Monitor Symptoms: Keep track of any additional symptoms outside of the missing period. Note things like mood changes, further spotting, abdominal pain, or any unusual discharge.
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Pregnancy Test: Before taking any further steps, consider taking a home pregnancy test to rule out pregnancy as a cause of your missed period. This should be done regardless of contraceptive use if there's a chance of pregnancy.
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Hydration & Nutrition: Focus on maintaining a balanced diet and staying well-hydrated to support overall health, as these can influence menstrual regularity.
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Relaxation Techniques: Managing stress is important, particularly with your history of PMDD. Incorporate relaxation techniques such as deep breathing, meditation, or gentle exercise to help alleviate symptoms.
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Consult a Healthcare Professional: Since your period is significantly overdue and considering your medical history, it would be prudent to contact your gynecologist for personalized advice. They may want to check for underlying hormonal issues or medication side effects.
Taking these steps can help clarify the situation and determine the best course of action. Your health and wellbeing are important, so don’t hesitate to seek further guidance, especially if your symptoms worsen or you have additional concerns.
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