Seeking Answers for Persistent Rash and Swollen Foot in My 64-Year-Old Husband
My husband, aged 64, has been grappling with an incessant itchy rash for the past three months, accompanied by slight swelling in one of his feet. He manages health issues with medications for high cholesterol, triglyceride levels, blood pressure, and diabetes. Interestingly, he worked close to the World Trade Center site from September 11, 2001, through 2007, but I’m unsure if this detail is pertinent. Additionally, he has a long history of heavy alcohol consumption, primarily preferring beer and Jack Daniel’s. The itchiness began around three months ago, initially localized to his back. After about two weeks, a rash emerged, predominantly affecting his legs, with some spread to his arms and upper back, but sparing his face and neck. We’ve eliminated potential triggers by reviewing his products—there has been no change in soap, shampoo, or laundry detergents, nor in his medication regimen. After persistent scratching, the rash became visible and began to itch as well. A visit to our primary care physician led to a prescription for prednisone, antihistamines, and a topical cream aimed at alleviating the itching and rash symptoms, but there was no improvement. Two weeks ago, the same physician reached out to a dermatologist to expedite my husband’s consultation. The dermatologist performed a punch biopsy, and although we received the results this past Monday, they yielded no definitive explanation for the rash. This morning, the dermatologist ordered blood tests, although I didn’t see the specifics of the tests. When I returned home from work tonight, my husband expressed concern about some swelling in one of his feet, mentioning he would go to the emergency room should it worsen. He is feeling utterly miserable, having managed to avoid the bar for three days now, which is a small victory. What could be causing this issue? Is there a possibility that the blood tests might clarify whether he’s dealing with an autoimmune condition or an adverse reaction to long-standing medications?
Answers (1)

6/27/2025, 12:20:43 AM
OpenHealth AI
It sounds like your husband is experiencing a challenging combination of symptoms, and I understand your concern for his well-being. The combination of an itchy rash that has spread, along with swelling in his foot, could potentially be linked to various underlying conditions. It’s great to see that he is already undergoing testing and consultation with healthcare professionals, which is paramount.
Key Points:
- Persistent Itchy Rash: This could be due to multiple causes, including allergic reactions, skin conditions (like eczema or psoriasis), or systemic issues (like autoimmune diseases).
- Swollen Foot: Swelling can indicate inflammation, fluid retention, or other systemic concerns. It could relate to his underlying health conditions or medication side effects.
Possible Causes:
- Autoimmune Conditions: Conditions like lupus or psoriasis could manifest with a skin rash and systemic symptoms. The blood tests your dermatologist ordered may help in ruling these out.
- Allergic Reactions: Sometimes medications or environmental allergens that may not be obvious can cause persistent rashes.
- Liver Function: Given his history of alcohol consumption, it's important to consider liver health, as alcohol can affect how the body processes medications and can lead to skin issues or swelling.
Next Steps:
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Monitor Symptoms: Keep a close eye on the rash and swelling. If the foot swelling worsens, or if he develops other symptoms like pain, redness, or increased difficulty moving, seek emergency care.
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Follow Up on Blood Tests: Wait for the results of the blood tests from the dermatologist. They might provide crucial information on whether there is an autoimmune condition or any other underlying issues associated with his medications.
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Continue Avoidance of Alcohol: Encourage your husband to avoid alcohol for the time being, as this can impact his overall health and may interfere with treatment outcomes.
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Symptom Management: While waiting for further evaluation, continue using the prescribed treatments and consider additional soothing remedies like oatmeal baths or cold compresses for the rash to help reduce itching.
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Document Changes: Keep a log of any changes in symptoms, including the rash's appearance, swelling levels, and any other systemic symptoms. This can help the healthcare team make more informed decisions.
Your husband's situation is complex, but it seems that he is in good hands with his healthcare providers. If you notice any significant changes or worsening symptoms, don't hesitate to seek immediate medical advice. You’re doing a great job supporting him, and hopefully, with further evaluation, he will find relief soon.
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