Inquiries Regarding Zepbound Experiences
I am a 43-year-old woman, who does not smoke, standing at 5 feet 4 inches and weighing 168 pounds. At the moment, I am not taking any medications, but I was previously on Zepbound at a dosage of 10mg. Earlier, I mentioned that after increasing my dosage from 7.5mg to 10mg, I began experiencing itchy welts. These welts were not localized at the injection sites but appeared randomly on my thighs, stomach, sides, and even my back. Importantly, I did not have any facial swelling or other typical symptoms associated with allergic reactions. Eventually, I started to believe that Zepbound was the cause of these welts, which was disheartening, considering that this medication has dramatically improved my quality of life over the last ten months (the welts began about 8-9 months into treatment). I have abstained from Zepbound for the past 30 days, with my final injection of the 10mg dose occurring over a month ago. Despite this hiatus, I continue to sporadically develop the welts, usually upon waking in the morning, although they sometimes arise at night as well. It seems unlikely that Zepbound could still be the culprit, given my absence from the medication for such an extended period. Tomorrow, I have an appointment with an allergist, and I hope to gain some clarity on this issue. I would appreciate any insights or recommendations from the community. Thank you for your support.
Answers (1)

6/26/2025, 7:20:36 PM
OpenHealth AI
I understand that you're experiencing ongoing issues with itchy welts after recently stopping Zepbound, which has otherwise positively impacted your life. It’s great to hear that you are seeking more information before your appointment with the allergist. Let's break this down.
Main Points:
- You’ve had itchy welts possibly related to Zepbound, but these are persisting even after stopping the medication.
- It's important to explore other potential causes for your symptoms.
Explanation:
Given that you experienced itchy welts after increasing your Zepbound dosage, it is reasonable to consider a hypersensitivity reaction. However, continuing welts a month after stopping Zepbound suggests that something else might be contributing to these symptoms. Allergies, skin conditions, stress, or other factors could also be responsible.
Next Steps:
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Keep a Symptom Diary: Before your allergist appointment, document when the welts appear, their duration, and any other symptoms you might notice. This will help your doctor identify patterns.
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Observe Your Environment: Consider any recent changes in products (soaps, detergents, fabrics) or environments (new home, pets) that might trigger skin reactions.
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Manage Allergens: Until your appointment, try to avoid common triggers like certain foods, fragrances, and known allergens.
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Hydration and Skin Care: Maintain good hydration and use gentle, fragrance-free skincare products to soothe your skin.
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Discuss with Your Allergist: During your upcoming appointment, convey your observations clearly. Your doctor may suggest tests to identify allergens or skin conditions that could be causing your welts.
Your proactive approach by consulting a specialist is vital, and I hope this information aids your dialogue with the allergist. It’s important to find a solution that maintains your improved quality of life. Feel free to share updates or additional questions after your appointment!
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