Insight Needed on Abnormal Test Results
I am a 35-year-old woman standing at 5 feet 4 inches tall and weighing 120 pounds. I am seeking clarity regarding some recent test findings. For the past several months, I have been experiencing a range of full-body symptoms and I feel as though my organs are not functioning properly. Despite various examinations, I have yet to receive a firm diagnosis. The tests, which were requested by my rheumatologist, returned several abnormal results that concern me. - Histone: 2.8 (high / strongly positive) - Chromatin: 2.4 (high / positive) - AST: 50 U/L (high) - ALT: 74 U/L (high) At present, I am prescribed metoprolol by my cardiologist to manage symptoms related to post-viral dysautonomia. Additionally, I take Allegra, Zyrtec, and Pepcid daily as recommended by my allergist due to mast cell-related issues, although I have not received acknowledgment of mast cell activation syndrome (MCAS). I’ve recently tapered off omeprazole, which was given to me by my GI doctor to alleviate acid reflux symptoms. My health challenges seem to have started after I contracted norovirus in December and was subsequently treated with Bactrim shortly afterward. Any insights or guidance regarding these test results would be greatly appreciated.
Answers (1)
6/26/2025, 4:20:41 PM
OpenHealth AI
Your situation with abnormal test results and ongoing symptoms is understandably concerning. The findings you shared, particularly the high histone and chromatin results alongside elevated liver enzymes (AST and ALT), suggest potential autoimmune or inflammatory processes, which can occur in conditions like lupus or other rheumatologic diseases. Given your symptoms and the background of post-viral dysautonomia, it's crucial to approach this methodically.
Key Points:
- Your abnormal test results, particularly the elevated histone and chromatin levels, may indicate autoimmune activity.
- Elevated liver enzymes (AST and ALT) warrant further exploration to understand their cause, especially since you have a history of health challenges.
- Continuous management of your existing conditions is essential while you seek further clarity on the new symptoms.
Explanation:
- Histone and Chromatin Antibodies: These are often associated with autoimmune diseases, such as lupus. High levels indicate that your immune system is possibly attacking your tissues.
- AST and ALT Elevation: These are enzymes that can indicate liver inflammation or damage. Numerous factors could contribute to their elevation, including medications, viral illnesses, or autoimmune activity.
- The backdrop of your norovirus infection and subsequent treatment could relate to your current health status, suggesting a post-viral syndrome.
Next Steps:
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Monitor Symptoms: Keep a detailed diary of your symptoms (timing, duration, severity) and note any changes in response to medications or lifestyle adjustments. This information can be incredibly helpful for your healthcare provider.
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Hydration and Nutrition: Ensure you stay well-hydrated and focus on a balanced diet to support your liver and overall health. Certain foods, like those rich in antioxidants (fruits and vegetables), could be beneficial.
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Communicate with Your Rheumatologist: Share your symptoms and test results explicitly with your rheumatologist. Ask for further clarification on the implications of your test results and discuss potential next steps. You may need additional testing, like an autoimmune panel, ultrasound for liver assessment, or a referral to a hepatologist.
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Be Cautious with Medications: As you just tapered off omeprazole, monitor for any changes in your symptoms related to acid reflux. Inform your doctor about this change to ensure they can manage your symptoms correctly.
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Discuss Concerns About MCAS: If mast cell activation syndrome is a concern, raising this topic with your allergist or rheumatologist would be valuable. They may suggest specific tests or management strategies.
Your proactive approach is essential, and focusing on understanding your symptoms while consulting with your healthcare team will provide the best path forward. Stay engaged with your providers and don’t hesitate to ask questions to advocate for your health effectively.
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