Exploring Cold Sensations at the Corner of the Mouth
User F19, standing at 5'9" and weighing 260 lbs, is currently prescribed multiple medications including Adderall, Propranolol, Doxepin, Zyrtec, Effexor, Elavil, Guanfacine, and Buspar, and also has Nexplanon. This individual has been diagnosed with several conditions, including Dysautonomia, Postural Orthostatic Tachycardia Syndrome (POTS), Complex Regional Pain Syndrome (CRPS) type 1, dermatographia, and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). In the last few hours, a peculiar cold sensation has developed in the right side of the lips and the outer mouth area, reaching towards the cheek. There are no noticeable differences felt inside the mouth, but the outside feels oddly chilly to the touch, causing mild discomfort. Sensation remains intact. Recently, they've also experienced increased itchiness, which is a new development. What could be causing this sensation? Is it something to worry about? It's certainly an unusual feeling.
Answers (1)

6/26/2025, 12:31:05 AM
OpenHealth AI
A cold sensation at the corner of the mouth, especially when combined with new itchiness, can be concerning but may not always indicate a serious issue. Given your complex medical history, this could stem from various factors, including medication side effects, nerve issues, or even skin reactions. Here's a breakdown of what might be causing your symptoms and the steps to consider.
Possible Causes
- Medication Side Effects: Some medications can lead to sensations like numbness, tingling, or coldness in various body parts.
- Neuropathy: Conditions affecting the nerves can cause unusual sensations. Since you have dysautonomia and POTS, these systems can contribute to altered sensations.
- Allergic Reaction: While dermatographia is a condition that involves skin sensitivity, new itchiness could suggest that you’re experiencing an allergic response or irritation.
- Localized Circulation Issues: Sometimes, a temporary disruption in blood flow can lead to cold feelings in an area of the face.
Immediate Steps to Take
- Monitor Symptoms: Keep track of the sensation and itchiness. Notate when it started, its severity, any triggers, and if it spreads or changes.
- Avoid Irritants: Stay away from any known allergens or irritants that could exacerbate your symptoms.
- Apply a Cool Compress: If it provides relief, gently applying a cool compress to the affected area can help with discomfort.
- Hydration and Skin Care: Ensure you're well-hydrated, and consider using a gentle moisturizer on the outer lip area to protect against dryness or irritation.
When to Seek Further Help
- If the cold sensation worsens, spreads, or if you notice swelling, rashes, or significant discomfort, it would be wise to reach out for a more thorough evaluation.
- Look for other symptoms like difficulty swallowing, severe pain, or changes in sensation elsewhere, which would warrant immediate attention.
Remember, while these sensations can be concerning, many causes are manageable or benign. Keep monitoring your symptoms closely, and don't hesitate to reach out for additional help if needed.
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