Uneven Pupil Size Concerns
I took a dose of 25 mg Zoloft last night, and I’m feeling quite anxious at the moment. I noticed something strange about my pupils; one seemed bigger than the other. While taking a selfie with the front camera, I observed a significant difference in the size of my pupils. Initially, I was on one side, and my pupils appeared uneven, but when I changed positions, it seemed like the other pupil became larger. This has caused me a lot of distress, as I am currently experiencing a severe panic attack.
Answers (1)

6/25/2025, 5:20:37 PM
OpenHealth AI
It's understandable to feel anxious when noticing changes in your body, especially during a panic attack. Uneven pupil size, known as anisocoria, can occur for various reasons, and your recent dose of Zoloft might be contributing to your current feelings of anxiety and physical symptoms. It's important to focus on calming down first since anxiety itself can sometimes lead to physical changes, including variations in pupil size.
Explanation
The size of your pupils can change in response to light, emotions, and even medications. The fact that you observed them changing depending on your position could be related to lighting or the way your eye muscles are reacting at that moment. Anisocoria can be benign and not a cause for immediate concern unless accompanied by other troubling symptoms like vision changes, severe headache, drooping eyelids, or other neurological symptoms.
Next Steps
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Calm Yourself: Try to engage in deep breathing or meditation techniques to help manage your anxiety. Inhale deeply through your nose for a count of four, hold for four, and exhale gently through your mouth for a count of four. Repeat this several times.
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Stay Hydrated: Drink a glass of water; dehydration can contribute to feelings of anxiety.
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Monitor Symptoms: Pay attention to your body. If the pupil size difference persists and you experience other symptoms (like blurred vision or severe headaches), consider monitoring this over a few hours.
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Limit Stimulants: Avoid caffeine or other stimulants, as they can exacerbate anxiety and potentially affect how your body reacts.
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Seek Support: If feelings of anxiety become overwhelming, reach out to a trusted friend, family member, or therapist to talk about it.
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Follow-Up: If you notice significant changes or new symptoms develop, consider keeping track of these and addressing them with a healthcare provider when you feel able.
You're not alone in experiencing distress, and it’s important to take care of both your physical and emotional well-being.
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