Combining Naproxen, Fluoxetine, and Promethazine: What You Need to Know
I have taken a total of 1500 mg of Naproxen, along with 220 mg of Fluoxetine and 350 mg of Promethazine. Is this a concerning combination? Previously, I was on Aripiprazole, but I've learned that it's generally considered to be a milder medication. 29-year-old male here.
Answers (1)
6/25/2025, 7:20:29 AM
OpenHealth AI
Combining Naproxen, Fluoxetine, and Promethazine raises some important considerations regarding medication interactions and potential side effects. Each medication serves different purposes and can interact in ways that require attention.
Explanation
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Naproxen is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain and inflammation. It can cause gastrointestinal issues or increase blood pressure in some individuals.
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Fluoxetine is a selective serotonin reuptake inhibitor (SSRI) commonly used to treat depression and anxiety. While generally safe, it can interact with other medications.
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Promethazine is an antihistamine that helps with allergies and nausea but can also cause sedation and may amplify the effects of other central nervous system depressants.
Concerns
- Potential Interactions: There is a risk of increased sedation when taking Promethazine with Fluoxetine, which may affect concentration or motor skills. Additionally, Naproxen and Fluoxetine can pose a risk for gastrointestinal bleeding, especially if taken together over the long term.
- Cumulative Effects: The combination may lead to increased sedation and weariness, particularly if you're also managing other medications or substances.
Next Steps
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Assess Yourself: Pay close attention to how you feel. Note any unusual symptoms such as excessive drowsiness, gastrointestinal issues, or mood changes.
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Avoid Alcohol: Steer clear of alcohol, as it can exacerbate the sedative effects of Promethazine and Fluoxetine.
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Schedule a Medication Review: Contact your healthcare provider to discuss your current medication regimen. It's crucial to review the dosages and duration, especially since the total doses seem higher than typical recommendations.
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Monitor for Adverse Effects: Be vigilant about monitoring for any severe side effects such as excessive drowsiness, confusion, or gastrointestinal bleeding (e.g., black or bloody stools) and seek help if you experience these symptoms.
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Keep a Medication Log: Document all medications and supplements you take, including doses, to share with your healthcare provider during your next visit.
Your health is important, and ensuring your medications work safely together is key for your well-being. If you have further questions or concerns, don’t hesitate to reach out for tailored advice tailored to your situation.
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