Managing Heavy Bleeding with Fibroids: Do I Need to Discontinue Mounjaro?
Previously, my excessive bleeding caused by fibroids was well-managed with an increased dosage of progesterone. However, after beginning Mounjaro, I’ve noticed a return to severe bleeding. I’ve been told to discontinue Mounjaro altogether. My goal is to shed some pounds as it may open the door to procedures like endometrial ablation or potentially a hysterectomy. Are there alternative solutions that would enable me to continue using Mounjaro? I experienced heavy bleeding when taking both the 2.5mg and 5mg doses. Could the increased bleeding be a result of the Mounjaro, or is it related to the weight loss itself? I’m currently succeeding in my weight loss journey, making the thought of stopping Mounjaro quite challenging. I would greatly appreciate your guidance on this matter.
Answers (1)

6/23/2025, 6:40:43 PM
OpenHealth AI
It's understandable that you're concerned about the return of heavy bleeding while trying to manage your fibroids and lose weight with Mounjaro. Here’s a structured response addressing your primary concerns:
Main Points:
- Heavy Bleeding and Mounjaro: It’s important to assess whether the bleeding is due to Mounjaro, weight loss, or the fibroids themselves.
- Alternative Solutions: There may be options to manage bleeding while continuing Mounjaro.
- Immediate Steps: Prioritize monitoring your symptoms and consider some self-care strategies.
Explanation:
Mounjaro (tirzepatide) is a medication used for weight management that can affect hormone levels and might exacerbate menstrual irregularities, especially in individuals with underlying conditions like fibroids. Fibroids can also contribute to heavy bleeding, and significant weight loss may temporarily disrupt hormonal balance, potentially impacting your menstrual cycle.
Understanding the connection is key. While Mounjaro may not directly cause heavy bleeding, its hormonal effects, combined with your existing condition, could trigger or worsen symptoms. It's crucial to distinguish what’s causing your symptoms, and consulting with a healthcare professional may be ideal to delve into this further.
Specific, Prioritized Next Steps:
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Monitor Your Symptoms: Keep a detailed record of your bleeding patterns, including the amount and duration of bleeding. Note any changes relative to your Mounjaro dosage and any other medications.
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Self-Care Measures:
- Maintain hydration and nutrition to support overall health.
- Use over-the-counter pain relief (like ibuprofen) if needed, but consult a pharmacy or healthcare provider on this based on your bleeding.
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Discuss with Your Healthcare Provider: Schedule a follow-up with your provider to discuss:
- The possibility of adjusting your dose or regimen of progesterone while continuing Mounjaro.
- Exploring hormone-related options that can help manage bleeding effectively.
- The option of monitoring hormonal levels to adjust treatments as necessary.
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Explore Other Weight Loss Aids: If needing to discontinue Mounjaro becomes necessary, talk to your provider about other weight loss options or lifestyle modifications that would support your goals without exacerbating your bleeding issues.
Your goal of weight loss is achievable, and focusing on a balanced approach that considers both your symptoms and your health goals is key. In the meantime, don't hesitate to reach out if you have further questions or need clarification on any points.
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