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Long-term Use of Acetaminophen: A Concern?

6/20/2025, 11:10:18 PMMale25-34

Hello, I’m a 37-year-old woman managing lupus and hypothyroidism, and I currently find myself struggling with weight issues. Over the past couple of days, I’ve been experiencing severe dental pain that has escalated to debilitating migraines, likely due to withdrawal from medication. For nearly two weeks, I’ve been consuming a total of 650 mg of acetaminophen twice each day. Now, I’m left wondering if I should be worried about this and if discontinuing its use is advisable. I can't resort to ibuprofen because I take a daily aspirin, which is compounded by my gastroesophageal reflux and a clotting condition known as APS. Prior to starting acetaminophen, I underwent blood tests and a liver ultrasound; thankfully, both results were normal. Given this context, should I feel safe stopping the acetaminophen, or is there cautiousness warranted?

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Answers (1)

Cony

6/20/2025, 11:10:36 PM

OpenHealth AI

It's understandable to be concerned about the long-term use of acetaminophen, especially given your existing health conditions. Acetaminophen is generally considered safe when used as directed, but there are some important aspects to consider in your situation.

Explanation

Acetaminophen is often used to manage pain and fever. For most adults, the recommended dosage is up to 4,000 mg per day. Your use of 1,300 mg daily (650 mg twice a day) is within that range, but ongoing use, particularly for dental pain or other issues, should be monitored closely. Given your lupus, hypothyroidism, and the medications you are on, it's essential to ensure that no contraindications exist.

Your migraine symptoms and dental pain might indeed warrant continuing some form of pain relief, but relying on acetaminophen long-term could raise concerns about potential liver stress, especially if you have any underlying risks. Since you've previously had normal liver tests, this may lessen concern, but it doesn't eliminate it.

Next Steps

  1. Consider Discontinuing Acetaminophen: If your pain allows, try tapering off the acetaminophen gradually, perhaps reducing to 650 mg once daily. Monitor how you feel during this time.

  2. Manage Pain Alternatives: Explore non-pharmacological options for pain relief that may include cold compresses for dental pain or relaxation techniques for migraines.

  3. Dental Care: Since your dental pain could be a significant factor, consider seeking dental advice as soon as possible to address the root cause of your pain, which might help with both your dental and migraine issues.

  4. Monitor Symptoms: Keep track of your pain levels and any potential withdrawal symptoms as you reduce acetaminophen. If your migraines worsen or do not improve, specifically note their frequency and severity.

  5. Stay Hydrated and Maintain Nutrition: As weight management is a concern, try to maintain hydration and focus on a balanced diet rich in fruits, vegetables, lean proteins, and whole grains to support overall health.

If you have significant side effects or concerns, please reflect on these with your healthcare provider who can provide personalized guidance suited to your comprehensive health picture. It's important to listen to your body as you make these adjustments.

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