Is This Practice Safe?
I have a query that might be best suited for a pharmacist: Recently, I came across a discussion in another forum regarding someone who opened a Vyvanse (Lisdexamfetamine) capsule, mixed it with water, and consumed it gradually throughout the day. They mentioned taking approximately 40% of the contents first thing in the morning, then dosing little by little thereafter, instead of swallowing the capsule all at once in the morning. I’m curious if this method is deemed safe? I plan to speak with my prescribing physician if I consider trying it out, but I couldn’t help but wonder if this is a common practice among others. What do you think? For context, I am a 26-year-old woman, 5’1”, currently prescribed 70mg of Vyvanse (generic).
Answers (1)

6/20/2025, 8:40:39 PM
OpenHealth AI
It’s great that you’re seeking information about your medication, and it’s wise to consider safety before trying any new method. Taking Vyvanse (lisdexamfetamine) in a way that deviates from the prescribed instructions can pose risks.
Main Points:
- Safety of Altering Dosing: Opening Vyvanse capsules and mixing the contents with water might lead to unpredictable effects on how the medication works in your body.
- Potential Risks: This method can affect the medication’s time-release properties, leading to a rapid release of the active ingredient and possibly causing side effects like increased heart rate, anxiety, or jitteriness.
Explanation:
Vyvanse is designed to be taken whole due to its formulation, which helps control how the medication is released into your system. Opening the capsule may disrupt this controlled-release system, causing a more intense effect initially and potentially leading to a decrease in effectiveness over time. Furthermore, dosing variably could increase the chances of side effects or lead to not getting the desired therapeutic effect.
Next Steps:
- Do Not Alter Your Dosing: Until you consult with your physician, it’s important to take the medication as prescribed. This helps ensure you are getting the safe and intended effects.
- Document Your Experience: Keep a log of how you feel on your current dosage. This can help you discuss your experiences effectively with your physician.
- Consult Your Physician: Schedule a conversation with your doctor about your curiosity. They can provide personalized advice and may suggest alternative methods if needed.
Your thoughtfulness about how to manage your health is commendable; just ensure that you prioritize safety by sticking to the prescribed method until you’ve had a chance to discuss your concerns with your doctor.
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