Reduction of Hard Lymph Node After Biopsy: Seeking Insights
Greetings, I’m a 43-year-old man weighing 185 pounds, and generally I maintain good health. I indulge in alcoholic beverages only during special celebrations, and I smoke a cigar a couple of times each year. Additionally, I am quite active, engaging in exercise five days every week. For the past month, I have been dealing with a hard, immobile lymph node measuring 3 centimeters. Aside from this issue, I haven’t experienced any other noticeable symptoms, apart from a severe cough that I believe stemmed from a bout of COVID I contracted in May after exposure from my two-year-old daughter. I underwent an ultrasound and a comprehensive CT scan with contrast, which revealed no other lumps apart from the one located in my neck. Four days ago, I had a fine needle biopsy performed, and I observed that the lump appeared considerably smaller later that same day. According to the biopsy report, they removed 6 milliliters of serosanguineous fluid. This seems likely to explain the reduction in size of the lymph node. Is it common practice for such a volume of fluid to be extracted during this kind of biopsy? My understanding was that fine needle biopsies typically collect just small samples of tissue. What does the presence of this fluid within the lymph node signify—good news or cause for concern? I’m feeling quite anxious as I await the results and just need to focus on relaxing. I hope to receive that anticipated phone call within the next week. Any insights would be greatly appreciated!
Answers (1)

6/19/2025, 3:20:47 PM
OpenHealth AI
It's understandable to feel anxious while waiting for biopsy results, especially given your experience with the hard lymph node and your current health status. Let's break down your situation and what it might mean.
Main Points:
- Volume of Fluid Extracted: It's not uncommon for a fine needle aspiration (FNA) to extract a significant amount of fluid if the lymph node is filled with it.
- Significance of the Fluid: The presence of serosanguineous fluid can indicate various conditions ranging from benign (like inflammation or infection) to more serious issues. The reduction in size of the lymph node after biopsy can be a positive sign, as it suggests that there may have been a lot of fluid within it.
Explanation:
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Fine Needle Biopsy (FNA): This procedure is designed to extract either cells or fluid from lesions or lymph nodes. In your case, it sounds like the lymph node was likely reactive or inflamed due to an underlying issue (like a previous infection), which can sometimes lead to fluid accumulation. The amount removed (6 milliliters) is certainly substantial for FNA, indicating that there was a notable amount of fluid.
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Potential Indications of the Fluid: The fluid could be a sign of a benign process, such as a reactive lymph node due to infection (like your prior COVID-19), or something else. The fact that you did not notice other symptoms is promising, but it’s important to await the results for a complete picture.
Next Steps:
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Stay Calm and Grounded: Try engaging in relaxing activities that you enjoy, such as light exercise or mindfulness practices. Managing your stress can help during this waiting period.
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Monitor Symptoms: Keep an eye on any changes in your body, such as new swelling, redness, fever, or an increase in cough. While it sounds like everything is stable, being aware can help you if circumstances change.
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Prepare for Your Results: Once you receive your results, jot down any questions or concerns you may have. This can help you clarify your understanding of the next steps in your care.
Remember that waiting for biopsy results can be an anxious time, but it’s also a step toward finding out what’s going on. Focus on maintaining your health and wellbeing during this time, and know that the information gathered will guide the next steps for your care. If you have further concerns or immediate symptoms arise, consider discussing them when you receive your results.
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