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Is It Possible to Experience Withdrawal Symptoms After Discontinuing GLP-1 Medications?

6/17/2025, 6:20:23 PMMale25-34

I’m a 29-year-old female weighing 155 pounds. For just over a year, I have been using a .25 dose of Wegovy (semaglutide). As I prepare for gallbladder surgery on July 14 to remove a 4.2cm gallstone, I felt it was necessary to pause my medication regimen. It has been three weeks since I stopped, and recently, I’ve been experiencing episodes of a racing heartbeat. Oddly enough, sitting exacerbates the sensation compared to standing, and at times, I feel faint. This symptom is new for me and usually lasts for about an hour. I searched for information regarding withdrawal symptoms from abruptly stopping this medication, but found no clear answers.

Weight ManagementNutritionAging

Answers (1)

Cony

6/17/2025, 6:20:42 PM

OpenHealth AI

It's understandable to have concerns about what you’re experiencing after stopping Wegovy. While GLP-1 medications like semaglutide are not typically associated with classic withdrawal symptoms, some individuals might notice changes in their body after discontinuation, particularly if they were using the medication for weight management or blood sugar control.

Key Points:

  1. Racing Heartbeat and Faintness: These symptoms can be concerning, especially if they are new and have changed with your posture.
  2. Discontinuation Effects: While not labeled as withdrawal, the body may respond to the absence of the medication, leading to changes in appetite, metabolism, or even anxiety.

Explanation:

Stopping Wegovy can lead to fluctuations in blood sugar levels and appetite, particularly if it has been influencing your body’s signals for a year. However, your racing heartbeat and feelings of faintness are important to monitor. Various factors, including stress, changes in physical activity, hydration levels, or underlying issues related to your upcoming surgery, could contribute to these feelings.

Next Steps:

  1. Hydration and Nutrition: Ensuring adequate hydration and balanced nutrition is crucial. Aim for a well-rounded diet rich in fruits, vegetables, whole grains, and lean proteins.
  2. Monitor Symptoms: Keep track of your symptoms, noting when they occur, their duration, and any accompanying factors (like stress, activity level, etc.). This could help identify patterns or triggers.
  3. Gentle Activity: If possible, incorporate light movements like walking or stretching to improve circulation and potentially alleviate racing heart sensations when sitting.
  4. Avoid Excessive Caffeine or Stimulants: Reducing caffeine or other stimulants can help if they are aggravating your heart sensations.
  5. Rest and Relaxation: Engage in relaxation techniques such as deep breathing, yoga, or meditation to help manage stress.

If these symptoms continue or worsen, or if you experience other concerning signs such as chest pain or severe faintness, it is important to seek medical attention promptly, as they could indicate a more serious issue needing evaluation. Please take care of yourself, especially with your surgery approaching.

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