Breast Cancer Insights: Is There a Link Between High Grade DCIS and Low Grade IDC?
Greetings. I'm a 39-year-old woman, weighing approximately 145 pounds and standing at 5'7", residing in the western part of the United States. I maintain a healthy lifestyle by avoiding alcohol and tobacco, following a pescatarian diet, and exercising moderately four to five times weekly. Sadly, my mother passed away at the age of 54 from a rare nasal cancer, having first been diagnosed at 41. This family history has prompted me to be proactive in seeking medical check-ups whenever I feel it's necessary. Recently, I opted to get a mammogram after experiencing a mild change — a subtle increase in sensitivity in my right areola just a few months back. Approximately three months ago, I received a diagnosis of Invasive Ductal Carcinoma located beneath my areola, measuring 12mm, classified as low grade 1, and exhibiting hormone receptor positivity (ER+ PR+) while being HER2 negative. Further analysis from my surgical pathology report revealed grade 3 Ductal Carcinoma In Situ (DCIS) with comedo necrosis, measuring 28mm, which was not detected during initial imaging. An MRI had noted enhancements less than one centimeter from the original lesion, which I believe pertains to the area adjacent to the IDC. As of now, I have yet to communicate with my oncological surgeon for further clarification. My inquiry revolves around the distinction between high and low grade DCIS. I have come across information suggesting that these grades arise through different biological pathways, with high grade DCIS typically progressing into high grade invasive ductal carcinoma, while low grade DCIS tends to develop into low grade IDC. From your knowledge or experience, is it often observed that grade 3 DCIS with comedo necrosis can coexist with, or potentially transform into, grade 1 IDC? I appreciate your insights on this matter. Thank you.
Answers (1)
6/17/2025, 6:10:44 AM
OpenHealth AI
It's understandable that you're seeking clarity on the relationship between your diagnosis of high grade Ductal Carcinoma In Situ (DCIS) and low grade Invasive Ductal Carcinoma (IDC). Let's break this down in simple terms.
Main Points:
-
DCIS and IDC Relationship: High grade DCIS can evolve into high grade IDC, while low grade DCIS typically correlates with low grade IDC. However, the presence of different grades can coexist and may behave variably together.
-
Implications of Your Diagnosis: Your current diagnosis indicates a combination of distinct grades of DCIS and IDC, which requires careful management.
Explanation:
Ductal Carcinoma In Situ (DCIS) is a non-invasive cancer that is contained within the ducts of the breast, while Invasive Ductal Carcinoma (IDC) involves cancer cells breaking through the duct walls and spreading into surrounding breast tissue. The grading system helps to evaluate the aggressiveness of these cancers.
- High Grade DCIS (like yours with comedo necrosis) is often associated with a higher likelihood of progression to invasive cancer compared to low grade DCIS. High grade lesions tend to grow faster and are less responsive to hormone therapies.
- Low Grade IDC, as in your case, indicates a slower-growing cancer that might be managed differently than more aggressive types.
Next Steps:
-
Clarify with Your Oncologist: Speak with your oncological surgeon about your specific situation and the potential implications of having both grades of DCIS and IDC. Ask them specifically how this may impact your treatment plan and prognosis.
-
Monitor Symptoms: Pay close attention to any changes in breast sensitivity, pain, or other breast health issues. Document these changes to discuss with your healthcare team.
-
Stay Informed: Read credible sources and guidelines from associations like the American Cancer Society or the National Breast Cancer Foundation to understand your condition better.
-
Support Systems: Consider connecting with support groups for individuals diagnosed with breast cancer; these can provide helpful resources and emotional support.
I appreciate your proactive approach to your health, especially given your family history. Don't hesitate to ask questions during your appointments; understanding your diagnosis is crucial for moving forward with a treatment plan that is right for you.
Related Questions
Understanding the Severity of Nitrous Oxide Inhalation
Approximately 22 to 26 hours have passed since I directly inhaled nitrous oxide from a whip cream canister, and I'm feeling uncertain about the situation. I'm pondering whether I should be concerned and what steps to take next. Visiting a physician is my last option at this point. I'm an 18-year-old male, stand at 6 feet tall, and weigh 166 pounds. I've been smoking for about three years but generally, my health is stable. Additionally, I am currently utilizing a fluticasone inhaler to manage my asthma.
Unexplained Illness
For more than two months now, my husband (54M) has been grappling with an unexplained illness. Despite undergoing a myriad of medical examinations, the doctors remain baffled and have yet to determine the underlying cause. He is currently experiencing several troubling symptoms, including: - Numbness affecting the left side of his face, particularly his chin and part of his lip. - Generalized body aches. - Discomfort at the base of his spine. - Persistent fatigue coupled with difficulties in achieving restful sleep. - Recurrent fevers, which tend to intensify during the night. The extensive tests he has undergone have ruled out various conditions, including: - Shingles - Epstein-Barr Virus - Antinuclear Antibody (ANA) levels - Rheumatoid factor tests - COVID-19 - Thyroid issues - Hepatitis B and C However, certain results have raised red flags: - Abnormal red blood cell counts - High erythrocyte sedimentation rate, indicating inflammation - Elevated ferritin levels - Increased C-reactive protein levels - Elevated aspartate transaminase My anxiety about his condition is growing, and I'm feeling increasingly uncertain about the next steps to take regarding his health.
Foot Bruise Following Exercise
A woman in her early 40s recently experienced an unusual issue. After taking a two-week hiatus from her regular high-impact exercise routine, which typically features numerous jumping lunges and various dynamic movements, she discovered a bruise on the top of her foot upon removing her socks at home. Additionally, she had been experiencing some tenderness in the soles of her feet, leading her to suspect that she might have pushed herself too hard during her initial return to workouts. Can anyone shed light on the potential causes of this bruise and suggest effective methods for addressing it?
Concerns About Grey Peptides
I'm curious if any healthcare experts have insight on grey peptides. My healthcare provider acquired them from a supplier called Peptide Crafters, specifically GLP-2. She assures me of their safety, and a few nurses I’ve chatted with have also indicated that I shouldn’t worry too much. As a 26-year-old woman, I find myself feeling anxious about my health. Am I making a mistake by considering these?
Inadvertently Used My Dog's Gabapentin
Recently, I made a rather foolish decision by taking my dog's gabapentin. I previously used this medication for my own issues, but it's been several years since I last took it. My dog was prescribed a dose, and in a moment of confusion, I consumed 300 mg, mistakenly believing it was equivalent to what humans take. Now, I am regretting this choice, concerned that since it was intended for my dog, I may experience adverse effects. The packaging indicates gabapentin at a dosage of 100 mg, yet it does not provide detailed ingredient information. A bit about myself: I am a 24-year-old woman, standing at 5 feet 2 inches and weighing 130 pounds. Additionally, I take Lexapro on a daily basis and occasionally smoke. I would appreciate any guidance on what I should do next.