Seeking Guidance on Chronic Urethritis Issues
I am reaching out for assistance regarding a troubling health situation. I'm a man in my early twenties and had an unprotected sexual encounter with a new partner in December 2023. Although the encounter was limited to oral sex, my partner's sexual history raised some concerns. Shortly thereafter, I developed a rash on the glans of my penis, resembling balanitis, along with some irritation under my foreskin. Additionally, I experienced cloudy white discharge, which led me to initially suspect a fungal infection. Unfortunately, applying topical clotrimazole did not yield any improvement. In response to my symptoms, I underwent several urine and blood tests. While I awaited the results, my doctor administered an injection of ceftriaxone and prescribed doxycycline. Remarkably, within four to five days, the rash subsided and the discharge transitioned to a clearer state. Despite these interventions, all test results returned negative—including tests for trichomoniasis, ureaplasma, and mycoplasma. Later in 2024, I had additional blood and urinalysis testing due to persistent symptoms of urethritis. I received a prolonged course of doxycycline but observed no significant changes. A couple of months back, I also attempted a regimen of five doses of fluconazole just in case I was dealing with a fungal infection, but this too proved ineffective. Currently, I am still grappling with urethritis and experiencing discomfort that feels akin to inflammation around my anus, which may be linked to prostate inflammation, leading to the sensation of a narrower passage. This discomfort makes cleaning after bowel movements more challenging and has increased my frequency of urination. I am also experiencing bloating and a general feeling of unease, along with greater fatigue, although I am uncertain if that's simply psychological. Recently, I underwent a Microgendx urine test after consulting with a urologist and tested positive for Enterococcus faecalis, revealing the presence of the tetM resistance gene. I was prescribed levofloxacin, but unfortunately, it has not provided any relief. I am contemplating a semen culture to identify any potential additional bacterial infections, but my doctor suggests trying yet another antibiotic. Having taken multiple antibiotics with little effect, I am concerned about the potential harm to my body, but I am also desperate to find a solution to eradicate this issue. If anyone has insights or advice on how to proceed, I would greatly appreciate it. This ongoing ordeal has significantly impacted my mental well-being and overall physical health. Thank you for any assistance you can provide.
Answers (1)

6/17/2025, 12:01:21 AM
OpenHealth AI
It sounds like you're facing a challenging and frustrating situation with your chronic urethritis symptoms, and I want to acknowledge how distressing that can be. Your symptoms and past treatments indicate that you've been proactive in seeking help, which is an important step in such complex cases.
Main Points:
- You have experienced chronic urethritis with associated symptoms and treatment failures.
- Enterococcus faecalis was identified, but antibiotic options may need reevaluation.
- There may be multiple factors at play, including anxiety and potential psychological impacts.
Explanation:
Chronic urethritis can be caused by various factors, including bacterial infections, irritation, or inflammation. The persistence of your symptoms despite multiple treatments suggests that the underlying issue could be multifaceted, including possible resistance to antibiotics, ongoing inflammation, or even a psychological component.
Next Steps:
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Semen Culture: Consider discussing the option of a semen culture with your healthcare provider. This might help identify less common bacterial infections that haven't been detected yet.
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Review and Evaluate Treatments: Talk openly with your urologist about the past treatments you've received and express your concerns regarding the need for more antibiotics. Investigate if any alternative treatments or combinations of medications might be beneficial.
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Consider a Multidisciplinary Approach: Include a consultation with a mental health professional who specializes in chronic illnesses. Anxiety and depression can amplify physical symptoms and lead to a cycle of distress that complicates recovery. Psychological support can be incredibly helpful in managing stress related to ongoing symptoms.
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Lifestyle Modifications: While continuing medical treatment, consider lifestyle changes that may help alleviate some symptoms:
- Hydration: Drink plenty of water to help flush your system.
- Diet: Avoid irritants like caffeine, spicy foods, and alcohol, which may exacerbate urinary symptoms.
- Hygiene Practices: Maintain good genital hygiene but avoid harsh soaps or irritants that can worsen irritation.
- Stress Management: Techniques such as mindfulness, meditation, or gentle exercise can help reduce overall stress and might improve your physical symptoms.
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Symptom Diary: Keep a detailed diary of your symptoms, dietary habits, urinary patterns, and emotional well-being. This can help you and your healthcare provider identify potential triggers or patterns over time.
Your situation is understandably distressing, but with continued collaboration with your healthcare team and possible lifestyle adjustments, there is hope for improvement. Take things one step at a time, and remember to care for your mental well-being as well during this process. If you have any more questions or need further assistance, please feel free to ask.
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