OpenHealth Q&A

Get answered by medical professionals

Guidance on Synthroid and Omeprazole Usage

4/22/2025, 8:40:21 PMMale25-34

A woman in her seventies has been on Synthroid for an extended period. Recently, she began experiencing some digestive challenges, prompting her physician to recommend omeprazole, to be taken once daily in the morning prior to meals. Along with this new medication, her doctor advised altering the timing for her Synthroid intake, which was initially taken in the morning before breakfast. However, specific details on how to adjust the timing, including when to take Synthroid and how to properly space the doses, were not provided. If anyone has any recommendations or information regarding the optimal timing for Synthroid in relation to omeprazole, I would greatly appreciate your insights. Thank you!

HeartburnIndigestionInternal Medicine

Answers (1)

Cony

4/22/2025, 8:40:37 PM

OpenHealth AI

To ensure the effective use of Synthroid (levothyroxine) and omeprazole together, it's important to properly space the timing of these medications. Here’s a structured overview of the key points regarding their usage.

Main Points

  • Timing Matters: Levothyroxine (Synthroid) should be taken on an empty stomach, while omeprazole works best when taken before meals.
  • Spaced Doses: It’s crucial to space these medications to maximize their effectiveness.

Explanation

Levothyroxine needs to be absorbed properly in the digestive system, which is why it's best taken on an empty stomach. Omeprazole, on the other hand, reduces stomach acid and is typically taken before meals to help with digestive issues such as heartburn or indigestion. Taking these medications too close together could hinder the absorption of Synthroid due to the change in stomach environment that omeprazole creates.

Next Steps

  1. Timing Adjustment: Have your loved one take Synthroid first thing in the morning with a full glass (8 ounces) of water, at least 30-60 minutes before breakfast. This helps to ensure it’s absorbed effectively.
  2. Omeprazole Timing: After taking Synthroid, wait at least 30 minutes to an hour before taking omeprazole—ideally before breakfast. This spacing can help both medications work as intended.
  3. Consistent Routine: Establish a daily routine for taking these medications to reinforce consistency and effectiveness.

Further, it can be beneficial to observe any changes in symptoms and communicate these to her healthcare provider, especially if any new digestive issues arise. If you have more questions or need assistance in monitoring her progress, feel free to ask!

Related Questions

Interpreting My Gastrointestinal Discomfort

A 26-year-old female, weighing 155 pounds, has a background of experiencing gastroesophageal reflux disease (GERD) and anxiety. She has been using marijuana for several years and is currently taking venlafaxine at a dosage of 150 mg each day. Residing in the Midwest USA, she identifies as white. On January 20th, she experienced what she initially believed to be a low blood sugar episode. Due to being preoccupied and busy, she had not consumed much food throughout the day. Consequently, she felt lightheaded, nauseated, pale, and was sweating. To alleviate these symptoms, she consumed around 60 to 80 grams of carbohydrates once they began, but it took roughly 2.5 hours for her to start feeling better. The following day, she faced additional discomforts including nausea, heartburn, body aches, trembling with chills and sweats, along with diarrhea. These symptoms persisted for a few days. By January 23rd, she consulted urgent care, where the medical team suspected a stomach virus and advised her to let it run its course. Regrettably, her stomach has not returned to its normal state since that incident. She has been experiencing occasional heartburn and indigestion reminiscent of her previous severe GERD episodes. Additionally, she is suffering from lower abdominal cramps, particularly triggered by consuming items like popcorn or spicy foods, which feels akin to irritable bowel syndrome (IBS) symptoms. During the height of her symptoms on January 20th, she ceased smoking. She partook in smoking a few times between January 24th and 28th, without noticing any changes in her symptoms – positive or negative – and has refrained from smoking since then. It is worth noting that she has not experienced any vomiting or severe abdominal pain typically associated with cannabinoid hyperemesis syndrome (CHS). Are her symptoms indicative of CHS? She intends to abstain from smoking yet seeks clarity on the underlying cause of her discomfort. She has read about post-viral IBS and is curious if the suspected stomach virus has reignited her GERD, which had been stable for several years.

BloatingIndigestionAcid Reflux
Male25-34
11 hours ago

Exploring Probiotic Effects and Antibiotic Strategies in Gut Health

Greetings, M30. Is it possible that consuming an excess of probiotics could lead to SIBO or a similar condition? Earlier this summer, I suffered from a campylobacter infection, and in an attempt to remedy that without realizing its full extent, I resorted to high doses of probiotics. This approach, however, only aggravated my situation. I experienced severe bloating, intensified brain fog—especially after consuming carbohydrates—and following a comprehensive examination of possible causes, including an initially misleading negative test for c. jejuni that later revealed IgG antibodies in my blood, I was prescribed rifaximin (200mg four times a day). Unfortunately, after five days of rifaximin treatment, my symptoms escalated dramatically, resulting in excruciating lower abdominal pain and a marked intolerance to carbohydrates. Through my research, I discovered that the probiotic strains I had been using were sensitive to antibiotics, so I requested that my physician switch my medication to amoxicillin, which promptly resolved the issues I was facing. Complicating matters, I later learned that I had been contending with an acute bartonella infection, which likely contributed to my motility problems. As the year progressed, I indulged in kimchi after having been on antibiotics for bartonella treatment for about a month. However, I had to stop the antibiotics over the Christmas holidays when I developed rashes from herpes on my face and required alternative treatment. Following my kimchi overindulgence, I began to experience bloating again, cognitive fog intensified, and I felt a toxin-like sensation after consuming larger amounts of carbohydrates, alongside a newfound intolerance to wheat products. My doctor once again prescribed rifaximin as the primary treatment, but I am starting to notice that familiar acidic sensation in my abdomen returning. Is this reaction indicative of die-off symptoms, or could it mean that rifaximin is targeting competitors of the kimchi bacteria in my gut, resulting in their proliferation and creating a cycle where lactic acid bacteria alter the colon's pH, promoting further growth of lactic acid producers? I suspect this situation mirrors what transpired during the summer months. Would switching back to amoxicillin be advisable, or might I need to consider amoxiclav instead, given that the kimchi contained fish sauce which might be a source of beta-lactamase? Best wishes,

BloatingStomach PainIndigestion
Male25-34
11 hours ago

Eight Years of Persistent ‘Hunger’—Is It a Functional Gut Disorder?

Greetings everyone, I’m a 28-year-old woman standing at 5 feet 4 inches, and for nearly eight years, I have struggled with a constant, hollow sensation in my upper abdomen that resembles hunger. Here are some key points about my experience: - This sensation arises between meals or soon after I have eaten. - It gets momentarily better after eating but eventually returns. - Though it feels like hunger, I know it's not genuine hunger. - Mornings are especially tough as the sensation intensifies. I maintain a regular meal schedule and consume enough calories without any restrictions. Currently, I find it difficult to trust my hunger cues, so I'm tracking my calorie intake. I do not take any medications and have previously used proton pump inhibitors without any noticeable improvement. Additionally, I neither smoke nor consume alcohol. Visits to my general practitioner have yielded no definitive diagnosis, with much of the feedback being centered on dietary adjustments. I am currently facing a waiting period of approximately eight months for a gastroscopy. Strangely, I also notice that I feel particularly weak during my workouts, despite my calorie intake being sufficient. Has anyone else faced a similar long-term issue? Did you find it to be functional dyspepsia, gastritis, visceral hypersensitivity, or something entirely different? Were you able to obtain assistance through a gastroenterologist, a dietitian, or therapy? Thanks for your insights!

IndigestionGastroenterologyNutrition
Male25-34
11 hours ago

Understanding My Lack of Appetite

I’m a 14-year-old girl about to turn 15, standing at 155 cm (5' 1'') and weighing around 53-54 kg. My exact weight remains unclear since I am battling anorexia and have been advised against using the scale. I am currently on a regimen of antidepressants (150mg of semonic daily) and antipsychotics (15mg of olanzapine). Along with my eating disorder, I've struggled with self-harm and have been diagnosed with a conduct disorder (though I'm unsure if that is the correct term in English as I'm receiving treatment in Spain). In September, coinciding with the start of the school year, I experienced a relapse regarding my eating disorder. This phase lasted a few weeks until I transitioned to homeschooling. Initially, recovery felt manageable; I experienced satiety quickly, and I was relieved to allow myself to eat once more. However, I’ve noticed a significant decrease in my appetite. I rarely feel hungry, and even when I do, it doesn't seem to bother me. I’ve lost the desire for typical meals, though I still find myself yearning for snacks, particularly sweets or salty options, which are much more appealing and easier to consume. Foods like rice are particularly challenging; I have to push myself to continue eating them because they don't excite me at all. I’m uncertain if this change is due to some underlying issue or merely stress, although I don't currently feel stressed. Perhaps my lack of physical activity contributes to my diminished appetite, as I haven't been particularly active and might not need as much food as others. It’s also worth noting that I haven’t grown taller for about a year or two, remaining at 5' 1''. This situation wouldn’t be as concerning if I weren’t dealing with anorexia, allowing me to simply eat less. Yet, given my background, I require supervision at mealtimes, which complicates my relationship with food. Whenever I lack the desire to eat, those around me jump to the conclusion that I am relapsing, which I am not. I enjoy food tremendously, especially sweets, and I snack throughout the day. It’s just the full meals that elude my cravings completely.

Food IntoleranceIndigestionNutrition
Male25-34
12 hours ago

Seeking Guidance for Persistent Abdominal Pain and Bowel Issues

I am a 54-year-old male reaching out to seek advice regarding ongoing complications related to bowel movement and abdominal discomfort. I have been experiencing a tendency for stools to become backed up in the ascending and transverse sections of my colon, coupled with persistent, diffuse pain in the central right side of my abdomen, particularly at the junction of the terminal ileum and cecum. The discomfort around the ileocecal valve manifests itself with noticeable grunting noises, especially after eating and during movement or when sitting upright. The pain intensifies with physical activity and tends to alleviate when I lie down. I frequently experience a nagging pressure in my lower abdomen, especially while standing or sitting. Following meals, I notice pain in the midgut area and at the terminal ileum-cecal juncture, surfacing about 30 to 60 minutes post-ingestion, alongside a late-day increase in tenderness in the ascending colon, which is exacerbated by movement or bending sideways. In a previous visit to the emergency department, a CT scan with contrast was performed, and the attending physician indicated that I was experiencing stool buildup without any obstruction. They noted an unusual angle concerning my terminal ileum's alignment with the cecum, suggesting it appeared taut. Unfortunately, this evaluation did not lead to any conclusive treatment or diagnosis, which leads me to wonder if there might be a congenital or mechanical issue at play in the ileocecal region. My medical tests have indicated elevated calprotectin levels of 804 and 360, alongside a C-reactive protein reading of 26. A CT angiogram on September 25 revealed the presence of stool in the terminal ileum, contributing to my concerns. I am inquiring whether there are additional tests I should consider beyond a supine CT. Thus far, I have undergone a CT scan with contrast, a CT enterography (which did not reveal Crohn’s disease), a pill camera test (the results were inconclusive), abdominal X-rays, and a Sitzmarker test (which passed through successfully). I have also had three colonoscopies; two of them were unable to navigate to the terminal ileum, while the last one managed to reach enough depth to perform a biopsy that revealed some minor erosions, supposedly related to stool buildup. I have not yet undergone any dynamic imaging or barium studies. My primary concern is that my symptoms are consistently recurring without any periods of relief or improvement. I would greatly appreciate any suggestions regarding further testing I should pursue prior to my upcoming gastrointestinal appointment. Thank you for your assistance!

Stomach PainIndigestionConstipation
Male25-34
12 hours ago