Elevated AST and ALT Levels: Seeking Insight
Greetings! I recently received the results of my blood test, and I’m feeling quite anxious. My AST level was recorded at 123 IU/L and my ALT at 61 IU/L, both of which are above the standard values. This is my first experience with elevated levels. While most of my results fell within normal parameters, a few approached the threshold: - **AST**: 123 (Standard Range: 13 - 39 IU/L) - **ALT**: 61 (Standard Range: 7 - 52 IU/L) - **RBC Count**: 5.61 (Standard Range: 4.34 - 5.60 m/mm³) - **Hemoglobin**: 16.5 (Standard Range: 13.0 - 17.0 g/dL) - **Hematocrit**: 49 (Standard Range: 38.6 - 49.2%) - **Eosinophils %**: 0.7 (Standard Range: 0.1 - 6.8%) - **Basophils %**: 0.6 (Standard Range: 0 - 2.0%) - **Monocytes Absolute**: 0.5 (Standard Range: 0.3 - 1.0 k/mm³) - **Eosinophils Absolute**: 0.0 (Standard Range: 0 - 0.5 k/mm³) I recently began new medications. In June, I started taking GLP-1 through Hims, and in September, I was prescribed the generic version of Adderall due to an ADHD diagnosis. Since starting the GLP-1, I have managed to lose 36 pounds, going from 231 to 194. I only shed 4 pounds between June and September, but the remaining weight loss occurred afterwards. For reference, I’m 5’8”, and I had been dealing with a significant BMI and elevated cholesterol levels. Additionally, I must mention that I was dehydrated when I took the test. This hydration issue has been persistent, exacerbated by the medications causing dehydration and constipation. I have been jogging, but just this week, I incorporated weightlifting, which has left me feeling quite sore. However, I had not lifted weights prior to the testing; the soreness has only set in recently. Admittedly, my dietary habits haven’t been particularly healthy either. I apologize for the lengthy message, but I am curious if these spikes in AST and ALT could be linked to dehydration or muscle soreness. Has anyone experienced something similar, and could offer their thoughts? My doctor won’t be available until Monday, and I’m feeling quite anxious about this. Thank you for any insights!
Answers (1)
3/29/2025, 1:20:42 AM
OpenHealth AI
Elevated AST (aspartate aminotransferase) and ALT (alanine aminotransferase) levels can indicate liver stress or damage, and your recent changes in medication, weight, and hydration status could be related. It's understandable to feel anxious, but there are steps you can take to address this.
Explanation
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Understanding AST and ALT: These enzymes are found in the liver, and elevated levels often suggest that the liver is under stress, possibly due to various reasons such as medication effects, dehydration, or even physical activity. AST can also be elevated due to muscle breakdown, so your recent weightlifting and soreness could be contributing factors.
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Dehydration's Role: Dehydration can concentrate blood enzymes, making their levels appear higher. Since you mentioned chronic dehydration exacerbated by your medications, this is a vital area to address.
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Diet and Lifestyle Impact: Poor dietary habits can influence liver health. Weight loss and changes in activity level can also send signals to your liver as it works to process nutrients and medications.
Next Steps
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Improve Hydration:
- Aim to drink at least 8-10 cups (64-80 oz) of clear fluids daily, adjusting based on activity level. Electrolyte drinks can also be beneficial, especially if you're dehydrated due to medication.
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Monitor Diet:
- Focus on a balanced diet rich in fruits, vegetables, whole grains, and lean proteins. Reduce processed foods, high sugars, and unhealthy fats. This will help support overall liver health.
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Assess Physical Activity:
- Gentle exercises like walking or light jogging might be better for now, especially if you're feeling sore. Once you’re well-hydrated and your body adjusts, gradually increase your weightlifting routine.
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Schedule Follow-Up Tests:
- When you see your doctor on Monday, discuss the possibility of repeating liver function tests in a few weeks to confirm whether the elevation persists or was temporary.
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Consider Medication Review:
- Inform your doctor about all medications and supplements you are taking, as they can sometimes impact liver enzymes.
Reassurance
While elevated AST and ALT can seem alarming, they are not uncommon, especially with your recent weight loss, hydration issues, and new medications. Following these steps can help support your body as you await further professional advice. Stay positive, and let me know if you have further questions or need additional information.
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